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Orlistat

How does it work?

Xenical capsules contain the active ingredient orlistat, which is a type of medicine called a lipase inhibitor. It is used to aid weight loss in people who are obese.

Orlistat is not absorbed into the bloodstream, but works locally in the stomach and small intestine, where it prevents the action of two compounds found in the digestive juices. These compounds (known as enzymes) are called gastric and pancreatic lipases. They normally break down fats that we consume in our diet.

The fats we consume in our diets are made of molecules that are too large to be absorbed from the gut into the bloodstream. They need to be broken down into smaller molecules during the process of digestion, in order to be absorbed into the bloodstream. Gastric and pancreatic lipases are the compounds in the gut that carry out this function.

Orlistat works by preventing gastric and pancreatic lipases from working. It is taken at mealtimes to prevent fat that is eaten in the meals from being broken down and absorbed by the body. This means the body cannot use the fat as a source of energy, or convert it into fat tissue. Instead, the fat is excreted in the faeces. This helps weight loss.

Orlistat is prescribed to aid weight loss in obese people who have a body mass index (BMI) of 30kg/m² or more. It can also be prescribed to overweight people who have a BMI of 28kg/m² or more, if they also have additional risk factors for obesity-related diseases.

Orlistat should be used in conjunction with a mildly low calorie diet. Ask your doctor, pharmacist or dietician for advice on what to eat while taking orlistat. Your doctor may ask you to stop treatment if you have been unable to lose at least five per cent of your body weight after 12 weeks of treatment.

What is it used for?

  • Obesity

Warning!

  • While taking this medicine you should be eating a nutritionally balanced diet rich in fruit and vegetables, with approximately 30 per cent of your calories obtained from fat. You are more likely to experience digestive side effects from this medicine if you take it with a meal very high in fat, so your daily intake of fat, carbohydrate and protein should be spread evenly over the three main meals.

  • This medicine should be taken immediately before, during, or up to one hour after each main meal. If a meal is missed, or contains no fat, you should leave out the dose. This is because the medicine will have no effect if no fat has been consumed.

  • This medicine may potentially impair the absorption of fat-soluble vitamins (A,D,E,K) from the gut. To ensure you receive adequate nutrition, your diet should be rich in fruit and vegetables. Your doctor may also recommend a multivitamin supplement. If you do take a multivitamin supplement, it should be taken at least 2 hours after your orlistat dose, or at bedtime.

  • If you experience severe or persistant rectal bleeding while taking this medicine you should consult your doctor so that this can be investigated.

  • This medicine can cause diarrhoea, which if severe, can reduce the effectiveness of oral contraceptive pills. Women taking the pill for contraception should therefore use an additional method of contraception, eg condoms, to prevent pregnancy, if they experience severe diarrhoea while taking this medicine.

  • This medicine has not been studied in children under 12 years of age, elderly people, or those with impaired liver or kidney function.

U.S. Federal law prohibits the importation of pharmaceuticals that are dispensed without a valid prescription. (21 U.S.C. § 353(b)(1))